pharmacology

Department of Pharmacology

The Department of Pharmacology located in the 3rd floor of the Preclinical Block with a total floor area of 18000 sq ft. It is well equipped with seminar halls, lecture halls, demonstration halls, practical halls, department library with modern audiovisual aids and adequate number of books and journals with Internet facilities. The department has a well organized museum displaying herbal drug specimens the chart exhibits with a section on “History of Medicine.” The department also has a well maintained animal house with adequate breeding facilities for laboratory animals.

The department also runs a Clinical Pharmacology Unit in KIMS Hospital for drug information services, clinical trial operations, adverse drug monitoring and Pharmacovigilance activities.

The department regularly organizes workshops and training programmes in good clinical practice and drug awareness programmes for clinicians and practitioners.

The department has sufficient number of senior and experienced faculty members with good academic credentials imparting quality teaching and engaged in research activities.

The department also runs MD Pharmacology course with 6 annual admissions.

  • Adequate facilities for basic experimental animal research available in the department and central animal house with facilities for housing and breeding the animals.
  • Adequate infrastructure / facilities available for undergraduate and postgraduate training programmes.
  • Infrastructure and documentation facilities available for Pharmacovigilance activities in the KIMS Hospital – drug information services, clinical trial registry, ADR monitoring and publication of monthly newsletters / drug updates.
  • Departmental library with recent issues of the textbooks, monographs, journals and printouts from national and international drug regulatory authorities.
Name Designation E Mail ID Photo
  Dr. H.P. Pundarikaksha, MD   Professor & HOD   drpundarikahp@gmail.com; adr.kims.pharma@gmail.com
  Dr. K. Girish, MD   Professor   drgirish_k@rediffmail.com
  Dr. K. Vasundara, MD   Associate Professor   vasundarakrishnaiah@yahoo.co.in
  Dr. B.R. Kanchan, MSc, PhD   Assistant Professor   star.kanchan@gmail.com
  Dr. R. Jyothi, MD   Assistant Professor   sanjyothi03@gmail.com
  Dr. R. Vijendra, MD   Assistant Professor   vijendra_ramaiah@yahoo.co.in
Dr. Priyanka  S Tutor
Dr.Akshatha Shivanna PG Cum Tutor
 

The Pharmacovigilance Unit has been started in the 5th Floor, OPD Block, KIMS Hospital, as a part of Clinical Pharmacology Services since May 2011, as per the guidelines stipulated by the MCI and the National Pharmacovigilance Programme, to document, monitor, evaluate and report adverse drug reactions (ADRs). A Pharmacovigilance Committee has been organized to supervise these activities.

The Pharmacovigilance Unit is undertaking awareness and training programmes about pharmacovigilance among doctors, nursing and paramedical staff of the KIMS Hospital about detecting and reporting adverse drug reactions. This programme is ongoing with regular educational and awareness meetings with junior and new doctors who join KIMS Hospital. The Pharmacovigilance Unit has also been undertaking activities such as collection and compiling of the adverse drug reactions which are reported to the Pharmacovigilance Unit. The ADRs are then analyzed for causality and then reported to the Regional Pharmacovigilance Monitoring Center in JSS College of Pharmacy, Mysore.

Apart from ADR monitoring, other activities like hospital antibiotic policy, prescription auditing, scrutiny of medical records, drug information services, clinical trial protocol design are also being planned and worked out. It is also proposed to organize workshops regarding the rationale in use of antibiotics, during internships, UG and PG programmes.

REPORTING OF ADRs: The voluntarily reported ADRs are assessed for causality based on the WHO Causality Assessment Scale and transmitted to the Regional ADR Monitoring Center, JSS College of Pharmacy, Mysore.

A total of 126 (male=78; female=48) ADRs were analyzed and reported during the period from January 2012 to December 2012. Causality assessment indicated 18 ADRs were possible and 108 ADRs were probable.

FREQUENCY OF PHARMACOVIGILANCE COMMITTEE MEETINGS: The KIMS Pharmacovigilance Committee meets twice in a year (March/April and October/November).

OTHER ACTIVITIES:

  1. Awareness and guidelines regarding generic prescribing.
  2. Generic pharmacy started in the hospital campus. Supervised and scrutinized by the pharmacovigilance committee.
  3. Registration and monitoring of clinical trials conducted by various departments at the KIMS Hospital & Research Center.
  4. Drug utilization studies as part of larger framework for the development of hospital drug policy.
  5. Recommendations for the hospital antibiotic policy.
  6. Activities to promote rational prescription of drugs and prevention of sales of any banned / spurious / irrational combination of drugs in the hospital pharmacy.
  7. Monthly publication of KIMS Pharmacovigilance newsletter/drug updates & news.
  1. An open-label multicenter study of the tolerability and response to escitalopram treatment in Indian patients with major depressive disorder. Charles Pinto, JK Trivedi, GK Vankar, PSVN. Sharma and Vikram Narasimha. J Indian Med Asso 2007; 105: 364-8 & 379.
  2. A brief history of diabetes mellitus. Kundu D, Angrish S, Vijendra R. Indian Medical Journal 2007. Vol 101;108-109.
  3. Research in clinical setting of escitalopram in the treatment of depressed and anxiety patients in India. Narasimha Vikram R. Indian Journal of Clinical Practice 2007. Vol 17;No.12: 21-27.
  4. Detection of Stress, Anxiety and Depression in IT/ ITES professionals in the Silicon Valley of India: A Preliminary study. SK Chaturvedi, S. Kalyanasundaram, A. Jagadish, Vikram Prabhu, Vikram Narasimha R. Primary Care & Community Psychiatry 2007, 12:2, 75-80.
  5. Randomized, double blind, parallel group, comparative study of Deanxit (flupentixol and melitracen) versus dothiepin in the treatment of anxiety and/or depression co-morbid in general medical illness. HK Naidu, OP Singh, Jagadish A, Narasimha Vikram R. Medicine Update. Vol 15.7.2007.
  6. Research in Clinical Setting (RICS) of 5mg escitalopram (Cipralex) in the symptomatic treatment of mild to moderate anxiety and depressed patients in India. Narasimha Vikram R. Indian Journal of Clinical Practice. Vol 18.7.2007.
  7. Chronic low back pain, psychosomatic symptoms and the role of antidepressants. Narasimha Vikram R. Medicine Update. December 2007.
  8. Safety and efficacy of escitalopram in post stroke depression. Rajesh B, Narasimha Vikram R, H.P. Pundarikaksha. Medicine Update. Vol15.No.9.2008.
  9. A sub-analysis of efficacy and tolerability of Deanxit (flupentixol and melitracen) versus dothiepin in the treatment of anxiety and/or depression co-morbid in gastrointestinal disorders. Philip Augustine, Sanjay Jain, Narasimha Vikram R. Gastroenterology Today. 2008;12:27-32.
  10. An imperative need for change in pharmacology curriculum – A pilot survey in interns. Vasundara K, Kanchan BR, Pundarikaksha HP, Prasanna PS, Girish K, Jyothi R. Indian Journal of Pharmacology. Dec 2010. Vol 42(6):420.
  11. A comparative study of the analgesic activity of H2 receptor antagonists. Somashekhar HS, Pundarikaksha HP. Pharmacology Online. 2010. Vol 3: 459-469.
  12. A comparative study of efficacy and tolerability of dorzolamide and timolol maleate in patients with primary open angle glaucoma. Anuradha HV, Pundarikaksha HP, Himamshu NVV. Journal of Pharmaceutical Research. July 2010. Vol 9(3):132-136.
  13. Natriuretic Peptides – An Overview. Vijendra R, Pundarikaksha HP, Girish K. RGUHS Journal of Medical Sciences. Feb 2011. Vol 1:44-47.
  14. Existing and expected practical medical pharmacology curriculum – A survey. Vasundara K, Pundarikaksha HP, Vijendra R, Prasanna PS, Girish K, Jyothi R. Journal of Clinical and Diagnostic Research. Apr 2011, Vol-5(2):340-343.
  15. Efficacy and Tolerability of Trandolapril In Mild To Moderate Hypertension: A Double Blind Comparison With Enalapril. Jyothi R, Pundarikaksha HP, Srinivasa Prabhu NC, Girish K, Vasundara K, Vijendra R. National Journal of Basic Medical Sciences. Apr 2011, Vol-1(4):225-228.
  16. A prospective study of cutaneous adverse drug reactions in a tertiary care hospital. Vijendra R, Pundarikaksha HP, Gopal MG, Girish K, Vasundara K, Jyothi R. National Journal of Basic Medical Sciences. 2012, vol-3(1): 44-51.
  17. Possible Case of Ofloxacin induced Thrombocytopenia and Hypokalemia:  A case report. Girish K, Vikram Reddy K, Harsha R. Research and Reviews: A Journal of Pharmacology. 2012, Vol 2(1):24-28.
  18. A Prospective Open Label Comparative Study of the Efficacy and Safety of Topical Loteprednol Etabonate and Topical Flurbiprofen Sodium in Patients with Postoperative Inflammation after Cataract Extraction. Sheshidhar GB, Pundarikaksha HP, Sowbhagya HN. Journal of Clinical and Diagnostic Research. 2012, Vol 6(9):1499-1503.
  19. A Study of Cardiovascular Complications of Disulfiram-Ethanol Reaction. Girish K, Pundarikaksha HP, Vijendra R, Jagadisha A.National Journal of Physiology, Pharmacy and Pharmacology: 2013; vol 3 (1): 35-42.
  20. Comparison of Rational Pharmacotherapy Approach by Medical Students with and without Guide to Good Prescribing Guidelines. Vasundara K, Vijendra R, Raghunandan R. National Journal of Physiology, Pharmacy and Pharmacology: 2013; vol 3 (1): 53-56.
  21. Comparison of the pattern, efficacy, and tolerability of self-medicated drugs in primary dysmenorrhea: A questionnaire based survey. Ramya S, Vasundara K, Gokul CG, Shilpa M. Indian Journal of Pharmacology: 2013; vol 45(2): 180-183.
  22. Evaluation of Hepatoprotective Activity of Ethanolic Extract of Acacia Catechu Wild in Paracetamol Induced Hepatotoxicity in Albino Rats. Bannale SG, Maniyar YA, Chikaraddy A, Kashinakunti SV, Pundarikaksha HP, Domble V, Manjula R. International Journal of Pharmacy and Biological Sciences: 2013; Vol 3 (2):264-270.
  23. A Study of the Pattern of NSAID Prescribing in Orthopedic Out Patient Practice. Jyothi R, Pallavi D, Pundarikaksha HP,  Sridharmurthy J.N, Girish K. National Journal of Basic Medical Sciences.
  24. A study on the Pattern of self-medication for Acne Vulgaris in Medical/paramedical students. Jyothi R, Deepa R, Pundarikaksha HP, Girish K. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2013;Vol 4(4):1551-1557.
  25. A Study on the Drug Prescribing Pattern in Para-Nasal Sinusitis at a Tertiary care hospital. Deepa R, Jyothi R, Pundarikaksha HP, Jagannath B.  National Journal of Physiology, Pharmacy & Pharmacology. 2014; Vol 4(3):167-171.
  26. Cost-Effectiveness Analysis of Baclofen and Chlordiazepoxide in Uncomplicated Alcohol Withdrawal Syndrome. Vikram R, Girish K, Pundarikaksha HP, Vijendra R, Jyothi R, Vasundara K. Indian Journal of Pharmacology. [Accepted for publication]
  27. Impact of Educational Session on Knowledge and Attitude towards Palliative Care among Undergraduate Medical, Nursing and Physiotherapy Students: A Comparative Study. Divyalasya TVS, Vasundara K, Pundarikaksha HP. International Journal of Basic & Clinical Pharmacology. [Accepted for publication]

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